Research on correlation and prognosis of plasma coagulation factor XIII and IL-17 levels in patients with cerebral infarction

Objective:To discuss the correlation and prognosis on the levels of plasma coagulation factorⅩⅢ(FⅩⅢ)and IL-17in patients with cerebral infarction.Method:①According to the infarction size of CT or MRI of head,50patients with cerebral infarction were divided into three groups:great dimension infarction group(infarction size10cm3),middle dimension infarction group(infarction size 4to 10cm3)and small dimension infarction group(infarction size4cm3).Healthy control group included 20cases.Damage degree of nerve function was evaluated according to NIHSS score.Anticoagulant specimens of cerebral infarction group were collected within 24h,at 3rd day,7th day and 14th day respectively.The levels of FⅩⅢ and IL-17were measured by enzyme linked immune double antibody sandwich assay.②According to NIHSS scores within 24hand 14th day of cerebral infarction group,recent prognosis was compared.Result:①The levels of FⅩⅢ and IL-17of great dimension infarction group within 24hwere obviously higher than those of control group(P0.01),the levels of FⅩⅢand IL-17of middle dimension infarction group and small dimension infarction group within 24hwere higher than those of control group(P0.05).②Compared with small dimension infarction group,the levels of FⅩⅢ and IL-17of great dimension infarction group were different(P0.05).③Along with the state of illness improved,the levels of FⅩⅢand IL-17had decline tendency(P0.05).④The level of FⅩⅢ was positively correlated with the recent prognosis in patients with cerebral infarction groups(r=0.33),the level of IL-17was positively correlated(r=0.31).Conclusion:The levels of FⅩ Ⅲ and IL-17in patients with cerebral infarction would have positive correlation with course and prognosis,and their changes could be used as diagnose indexes of treatment and prognosis.