Syntheses and the antifungal activity of 3-bromo-4-thiochrom(an)ones

Aim To design and synthesize the 3-bromo-4-thiochrom(an)ones,and to value their antifungal activity. Methods BZ] The target compounds were prepared from the thiochromanones through bromination and oxidation,their antifungal effects were tested in vitro . Results Nine new compounds were synthesized.The structures of these compounds were confirmed by IR, 1H-NMR and elemental analyses.The compound The target compounds were prepared from the thiochromanones through bromination and oxidation,their antifungal effects were tested in vitro . Results Nine new compounds were synthesized.The structures of these compounds were confirmed by IR, 1H-NMR and elemental analyses.The compound Ⅴ_b exhibited excellent antifungal activity.Its MIC value was below or equal to that of the control. Conclusion The 3-bromo substituted thiochromanones show potent antifungal activity.