Yang Liu, Wei Luo, L Sun, Chun Guo
Abstract
A series of 3-substituted thiochromanones has been prepared. Their structures were confirmed by H(1)-NMR and HRMS. All of the synthesized compounds were screened for antifungal activity against ten fungi species in vitro. The compounds 2f and 2g were more efficient than the control drug, ketoconazole.
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A series of 3-substituted thiochromanones has been prepared. Their structures were confirmed by H(1)-NMR and HRMS. All of the synthesized compounds were screened for antifungal activity against ten fungi species in vitro. The compounds 2f and 2g were more efficient than the control drug, ketoconazole.
Key concepts: Ketoconazole, Antifungal, Chemistry, In vitro, Drug, Antifungal drug, Stereochemistry, Pharmacology