Clinical Significance of Measurement of T Lymphocyte Subsets in Peripheral Blood of Patients with Acute Myelogenous Leukemia

To evaluate the clinical significance of the changes of T lymphocyte subsets in patients with acute myeloid leukemia before and after therapy.Thirty acute myeloid leukemia patients who were confirmedly diagnosed but not treated were selected as new diagnosis group;Twenty-six patients completely remitted after chemical therapy was definite as complete remission group and 30 normal subjects were enrolled as control group.The changes of T lymphocyte subsets in three groups were examined by flow cytometry.The results showed that the ratio of CD3+T cells,CD4+T cells,CD8+T cells and CD4+/CD8+ in new diagnosis group were significantly different lower that that of complete remission group and controls(P0.05),and the ratio of CD4+T cells,CD8+T cells and CD4/CD8 in complete remission group were significantly lower than that of controls(P0.05).The cellular immune function of T lymphocyte is abnormal in patients with acute myelogenous leukemia,and the T lymphocyte subsets in patient of complete remission group are also lower than that of control group.