Clinical Significance of T Lymphocyte Subsets of Peripheral Blood in Patients with Acute Leukemia

Objective To evaluate the clinical significance of the changes in T lymphocyte subsets of peripheral blood in patients with acute leukemia.Methods Sixty cases with acute leukemia were divided into two groups:Group A(n=30)who were confirmedly diagnosed but not yet treated;Group B(n=30) who were confirmedly diagnosed and treated systematically with chemo-therapy ;And 30 normal subjects were enrolled as control group.We examined T lymphocyte subsets by APAAP,including the ratios of CD+_3T cells,CD+_4T cells,CD+_8T cells and CD+_4/CD+_8.Results Group A was significantly different from Group B and the control group in ratios of CD+_3T cells,CD+_4T cells,CD+_8T cells and CD+_4/CD+_8(P0.05);There was no significant difference in them between Group B and the control group(P0.05).Conclusion T lymphocyte subsets were markedly changed in Group A,but recovered essentially to normal after treatment.It shows that cell immunity has close correlation with genesis,development and turnover of leukemia.