Analysis of T lymphocyte subsets and CD56+ cell in peripheral blood of patients with acute myeloid leukemia and its clinical significance

Objective:To study the changes of T lymphocyte subsets and CD56+ cells in peripheral blood of patients with acute medloid leukemia and its clinical significance.Methods: AML patients who were confirmedly diagnosis but not yet treated as Group A(n=30);patients AML patients who were confirmedly diagnosed and treated systematically with chemo-therapy and reach complete remission as Group B(n=30);And 30 health people were enrolled as control group.We analyzed T lymphocyte subsets and CD56+ cells by flow cytometry,and examined HB and Alb level in different CD56+ cell expression group.Results: Group A was significantly different from Group B and the control group in ratios of CD3+T cells,CD4+T cells,CD8+T cells and CD4+/CD8+(P0.05);There was no significant difference in them between Group B and the control group(P0.05).Patients of Group A who having more than 25% CD56+ cell were 40%(12/30),while only 10%(3/30) in Group B.Patients who having higher CD56+ cell percentage were associated with low HB and Alb.Conclusion: Change of T lymphocyte subsets were associated with progress or prognosis of acute meyloid leukemia.Higher CD56+ cell xepression perpahs were associated with poor prognosis.