Analysis of drug resistance and distribution of 472 strains of Escherichia coli

OBJECTIVE To investigate drug resistance and specimen sources of Escherichia coli in hospital,so as to guide the clinical treatment and control of nosocomial infections.METHODS A total of 472 strains of E.coli were collected from June 2010-March 2011,and the drug resistance rates and specimen sources were analyzed retrospectively.RESULTS The resistance rates of the 472 strains of E.coli to imipenem,meropenem,and ertapenem were 0;the resistance rates to piperacillin/tazobactam,cefoxitin,amoxicillin/clavulanic,cefepime,ceftazidime,aztreonam,tobramycin,cidomycin,levofloxacin,ciprofloxacin,and cefotaxime varied from 7.8% to 58.5%;the resistance rates to sulfamethoxazole/trimethoprim,cefazolin,and ampicillin were 63.3%,73.9%,and 82.0%,respectively;472 strains of E.coli were mainly detected from sputum(33.1%) and urine(29.0%).CONCLUSION E.coli is the common pathogen which can cause respiratory tract infections and urinary tract infections.Antibiotics should be chosen in the clinical practice according to the characteristics of drug resistance.