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The Protective Effect against Acute Liver Injury in Mice by 4acetoxy-2benzoxazolone

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Abstract

Objective To evaluate protective effect of 4acetoxy-2benzoxazolone on CCL4-induced acute liver fibrosis.Methods The acute liver injury model was established by intraperitoneal injection of CCl4.After treating with different doses of AcO-BOA,the levels of serum alanine aminotranferase(ALT),aspartate aminotransferase(AST) and superoxide dismutase(SOD),glutathione peroxidase(GSH),malondialdehyde(MDA)in liver tissues were determined.Results Serum ALT,AST levels and MDA content in liver tissue were significantly decreased and SOD,GSH,levels in liver tissues were obviously elevated by the administration of AcO-BOA(P0.05).Conclusion AcO-BOA has the protective effect on acute liver fibrosis in mice.

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What this paper is about

Objective To evaluate protective effect of 4acetoxy-2benzoxazolone on CCL4-induced acute liver fibrosis.Methods The acute liver injury model was established by intraperitoneal injection of CCl4.After treating with different doses of AcO-BOA,the levels of serum alanine aminotranferase(ALT),aspartate aminotransferase(AST) and superoxide dismutase(SOD),glutathione peroxidase(GSH),malondialdehyde(MDA)in liver tissues were determined.Results Serum ALT,AST levels and MDA content in liver tissue were significantly decreased and SOD,GSH,levels in liver tissues were obviously elevated by the administration of AcO-BOA(P0.05).Conclusion AcO-BOA has the protective effect on acute liver fibrosis in mice.

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Available abstract

Objective To evaluate protective effect of 4acetoxy-2benzoxazolone on CCL4-induced acute liver fibrosis.Methods The acute liver injury model was established by intraperitoneal injection of CCl4.After treating with different doses of AcO-BOA,the levels of serum alanine aminotranferase(ALT),aspartate aminotransferase(AST) and superoxide dismutase(SOD),glutathione peroxidase(GSH),malondialdehyde(MDA)in liver tissues were determined.Results Serum ALT,AST levels and MDA content in liver tissue were significantly decreased and SOD,GSH,levels in liver tissues were obviously elevated by the administration of AcO-BOA(P0.05).Conclusion AcO-BOA has the protective effect on acute liver fibrosis in mice.

Key concepts: Malondialdehyde, Superoxide dismutase, Glutathione peroxidase, Glutathione, CCL4, Alanine aminotransferase, Liver fibrosis, Liver injury

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