Protective effect of 4-Hydroxy-2-benzoxazolone against acute liver injury in mice

Objective To study the protective effect of 4-Hydroxy-2-benzoxazolone(HBOA) against liver injury induced by carbon tetrachloride(CCl4) in mice. Methods The acute liver injury model was prepared by the intraperitoneal injection of carbon tetrachloride.The levels of ALT,AST in serum and levels of MDA,SOD and GSH in liver tissue were measured and hepatic histological changes were observed by optical microscope in order to evaluate the protective effects of HBOA. Results Compared with control group,the levels of serum ALT,AST and MDA in liver tissue were decreased significantly,the levels of SOD,GSH in liver tissue were increased obviously.Histological results showed that HBOA could ameliorate histological damages induced by CCl4 in liver. Conclusion HBOA has protective effects against acute hepatic injury induced by CCl4 in mice.