2007•Zhonghua zhongyiyao xuekanRequires access

Protective Effects of Compound HuangGen on Acute Liver Injury

Xiaolei Zhou

Abstract

Objective:To investigate the protective effect of Compound HuangGen on acute liver injury in mice.Methods:The models of hepatic damage of acute were induced by CCL4,D-GalN.The ALT,AST level in serum and MDA content,SOD,GSH-PX activites in liver homogenate,Pathology of liver were observed.Results:Compound HuangGen was found to significantly decrease the serum transaminase activities,Meanwhile Compound HuangGen also decreased MDA content and prevented the reduction of SOD,GSH-PX activities in liver homogenate.Conclusion: Compound HuangGen show significant protective action on acute liver injury in mice.

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Key concepts: Liver injury, Glutathione, Pharmacology, Medicine, Aspartate transaminase, Liver damage, Transaminase, CCL4