Levels of serum vWF in Uygur patients with acute coronary syndrome and relevant factors

Objective To investigate the levels of serum von Willebrand factor(vWF) in Uygur patients with acute coronary syndrome and study the possible correlations of serum vWF levels with blood pressure,blood lipids and blood glucose.Methods Totally 365 patients who were hospitalized in the department of cardiology of the People′s Hospital of Xinjiang Uygur Autonomous Region were divided into acute coronary syndrome group(n = 208) and control group(n = 157) according to their coronary angiography.Their height,weight and blood pressure were measured for all the patients.With collected fasting venous blood sample,theirblood glucose and blood lipids were tested and the levels of serum vWF were examined by enzyme linked immunosorbent assay.Results Compared with the control group,the level of serum vWF in the acute coronary syndrome group was significantly increased(P 0.01).In the acute coronary syndrome group,the levels of serum vWF were positively correlated with systolic blood pressure,diastolic blood pressure,triacylglycerol,low density lipoprotein cholesterol and fasting blood glucose(r = 0.708,0.669,0.756,0.878 and 0.883 respectively; P 0.01).Multiple linear stepwise regression analysis revealed that diastolic blood pressure,triacylglycerol,low density lipoprotein cholesterol and fasting blood glucose were the independent determinants of vWF levels(P 0.01).Conclusions The levels of serum vWF may increase in patients with acute coronary syndrome and there are certain correlations between serum vWF and blood pressure,blood lipids and fasting blood glucose.