Correlation among serum sVCAM-1,vWF levels and severity of coronary atherosclerosis

Objective:To explore the relationship among serum sVCAM-1,vWF levels and severity of coronary atherosclerosis.Methods:The concentrations of serumsVCAM-1 and vWF were assayed by means of enzyme linked immunosorbant assay(ELISA);the severity of coronary atherosclerosis was evaluated by coronary angiography and its Gensini's score in 51 patients with acute coronary syndrome(ACS),25 patients with stable angina pectoris(SAP) and 30 normal controls.Results:The concentrations of serum sVCAM-1 and vWF were significantly higher in ACS and SAP patients than those in normal controls(P0.001);the concentrations of serum sVCAM-1 in AMI patients were the highest and the concentrations of serum vWF were no significant difference between AMI and UAP patients.There was a significant positive correlation among the sVCAM,vWF and Gensini's score(r=0.642,P0.001;r=0.501,P0.01 respectively).Conclusion:The levels of serum sVCAM-1 and vWF may reflact the severity of coronary atherosclerosis.