Changes of von Willebrand Factor in Senile Patients with Type 2 Diabetes Mellitus and Its Relationship with Coronary Artery Disease

Objective To investigate the changes of von Willebrand factor(vWF) in senile patients with type 2 diabetes mellitus(T2DM) and its relationship with coronary artery disease(CAD).Methods Totally 115 senile T2DM patients(T2DM group) and 122 senile patients without diabetes(control group) were included in this study.The level of serum vWF,fasting glucose,HbA1c,cholesterol,low-density lipoprotein,high-density lipoprotein,triglycerides,uric acid,fibrinogen,and D-dimer were measured.Creatinine ratio of urinary albumin was measured in a first-morning-void urine sample.Clinical data and some biochemical items were compared between the T2DM group and control group and between those with or without CAD.The correlation of these items was analyzed simultaneously.Results Compared with the control group,the T2DM group had significantly higher vWF level((189.8±56.2)% vs(140.3±35.6)%,P0.01).Inside the T2DM group,vWF in patients with coronary artery disease(CAD) was significantly higher than in those without CAD((197.3±52.5)% vs(172.8±54.5)%,P0.05).No correlation was observed between vWF and other clinical items.Conclusion Senile T2DM patients tend to have higher vWF levels,which shows certain association with CAD.