Application of Intrathoracic Closed Drainage of Central Venous Catheter and Intrapleural Urokinase in Treatment of Encapsulated Tuberculous Pleurisy

To investigate the effects of closed drainage by central venous catheter and intrapleural urokinase in the treatment of encapsulated tuberculous pleurisy(ETP).Methods:40 cases with ETP were randomly divided into two groups: treatment group(20 cases)and control group(20 cases).The patients in treatment group was intrapleurally injected with urokinase 100,000 IU plus 20ml of 0.9% N.S by central venous catheter,while the control group was injected with 20ml of 0.9% N.S. Results:The mean volume of drainage fluid in the treatment group was more.Pleura adhesion disappearance(PAD)was 15 cases and the control group was only 2 cases of PAD.2 months later,guided by B-ultrasonography,the mean thickness of pleura in treatment group was(2.5+0.8)mm but(9.8+1.6)mm in control group(P＜0.01).The extent of chest collapse was also different, 5.3+1.6% in the treatmem group and 11.1+2.7% in the control group.There were significant differences in arterial blood gas analysis and lung function before and after trapleural urokinase therapy(P＜0.01).Conclusion:Intraplearal urokinase injection treatment can effectively increase the drainage,decrease pleura adhesion and pleural thickening,and improve pulmonary function of patients.