Effect of Intrapleural Injection of Urokinase and Draining by Indwelling Central Venous Catheters in Patients with Tuberculous Pleural Effusion

To observe the clinical effect of intrapleural injection of urokinase(UK)and draining with indwelling central venous catheter in patients with tuberculous exudative pleurids.Methods:52 cases of patients with large amounts of pleural effusion by tuberculos exudative pleuritis were randomly divided into treated group(n=27)and control group(n=25).The control group was given conventional drug treatment and the traditional simple thoracic cavity puncture pumping fluids(three times every week);to oral prednisone 15～30mg.d—1 in the patients with acute systemic intoxication,reduced 5～10mg every week,treated for 4-6 weeks.Based on conventional drug treatment,in the treated group,the central venous catheterization was put into thoracic cavity to drain the pleural effusion,then 100,000U～200,000U urokinase was injected into thoracic cavity,draining pleural effusion again after 24 hours,after that,draining again and again until the pleural effusion was exhausted,and then pulling out the central venous catheter.Results:The average hospitalization time:the treated group was(12.3±6.6)days,but the control group was(20.4±7.9)days.The average hospitalization total costs:the treated group was(2219.5±1161.3)Yuan;but the control group was(2721.9±1711.4)Yuan.After three months,the pleural thickness in treated group was(1.00+0.23)mm,but the control group's was(2.1±0.31)mm;there were no complications occurred in the treated group,but 5 cases of complication,in the control group There were significant difference between the two groups(p＜0.05 or p＜0.01).Conclusion:Intrapleural injection of urokinase(UK) and draining with the indwelling central venous catheter in patients with tuberculous exudative pleurifis could shorten hospitalization time and reduce hospitalization cost.It could also prevent the pleural thickening and adhesion,which is effective, simple and less side effects.