Incidence Rate of Bunging and Tolerance of Closed Drainage of Thoracic Cavity with Urokinase in Douching of Central Venous Catheter

Objective To compare the incidence rate of bunging and tolerance for pleural effusion by closed drainage of thoracic cavity between central venous catheter with Urokinase douching and routine method. Methods A total of 73 inpatients with pleural effusion during October 2009 and August 2012 were divided into three groups. Patients in group A( n = 21) were inserted central venous catheter; patients in group B( n = 18) were indwelled the same central venous catheter and injected 10wu urokinase into pectoral cavity everyday; patients in control group( n = 34) received routine intrathoracic cannula of closed drainage. After treatment for one week,the incidence rate of bunging and tolerance in three groups were compared. Results The incidence rates of bunging in group A and B,and control group were42. 9%( 9 /21),27. 8%( 5 /18) and 14. 7%( 5 /34) respectively,and which in group A was significantly higher than that in control group( χ2= 5. 422,P = 0. 020). The total rate of tolerance( 92. 3%) in group A and B( 55. 9%) was significantly higher than that in control group( χ2= 12. 973,P = 0. 000),which showed that group A and B had better tolerance. Conclusion Urokinase has some action in reduction of incidence rate of bunging in closed drainage of thoracic cavity. Patients' tolerance by using central venous catheter is better than by using routine thoracic close drainage.