Observation on the results of immunization with human rabies immunoglobulin

Objective To understand the effect and the adverse reactions in exposed population immunized with rabies immune globulin. Methods Based on the exposed extent, people exposed to rabies were divided into two groups, one immunized with rabies vaccine and rabies immune globulin, another one were only injected with rabies vaccine. The level of IgG antibody in subjects of the two groups were determined 3 and 15 days after immunization. Results The antibody positive rates in the groups immunized with rabies vaccine and rabies immunoglobulin 3 and 15 days after immunization were 91.1% and 98.8%, showing significant difference with general adverse reactions and local reaction of 3.5% and 13%. The antibody positive rates in the subjects immunized with rabies vaccine alone 3 and 15 days after immunization were 0 and 95.2% with general adverse reactions and local reaction of 3.1% and 1.1%. Conclusion Antibody to rabies virus can appear early in subjects immunized with rabies vaccine and immunoglobulin without apparent adverse reactions.