Postoperative analgesia with sufentanil combined with flurbiprofen axetil in patients with lower limbs operation

Objective To compare the efficacy and safety between sufentanil alone and sufentanil combined with flurbiprofen in patient controlled intravenous analgesia (PCIA) for patients with lower limbs operation. Methods Eighty patients with lower limbs surgery were randomly assigned to sufentanil (group S; n = 40) or sufentanil + flubiprofen (group SF; n = 40) groups. In group S, 100 μg sufentanil and 10 mg azsetron in 100 ml saline were administrated intravenously after operation, maintaining 2 ml/h with a prime dose of 0.5 ml for 15 min. In group SF, 50 mg flurbiprofen was infused 30 min before the end of operation, then 75 μg sufentanil + 100 mg flubiprofen + 10 mg azsetron in 100 ml saline were given by PICA pump. The scores of analgesia and sedation in the time points of 4, 12, 24 and 48 h after operation and the incidence of adverse effects were obtained in two groups. Results The score of analgesia and sedation in group SF were higher than that in group F. The incidence of adverse effects in group SF was lower than that in group S. Conclusion The use of sufentanil combined with flurbiprofen resulted in analgesia with less opoid consumption as compared with sufentanil alone in PCIA for patients with low limbs operation.