Effects of flurbiprofen axefil combined with sufentanil for postoperative analgesia in elderly patients

Objective To investigate the efficacy and safety of flurbiprofen axefil combined with sufentanil on postoperative pain in elderly patients and to explore the optimizing medication.Methods Sixty patients(ASA Ⅰor Ⅱ) aged 65-85 yrs undergoing elective upper abdominal surgery were randomly divided into four groups(n =15 each).In A group flurbiprofen axefil 50 mg was given intravenausty after the surgery,with sufentanil 100 μg in PCA pump.In B group flurbiprofen axefil 150 mg+ sufentanil 75 μg was added in PCA.In C group flurbiprofen axefil 50 mg was given intravenausty with flurbiprofen axefil 150 mg + sufentanil 50 μg in PCA.In D group sufentanil 100 μg was added in PCA.VAS score,Ramsay sedation score,the cumulative sufentanil consumption,the number of atempts,number of successful deliveries and side-effects were evaluated at 0,4,8,12 and 24 h after the surgery.The awakening time and extubation time was also recorded.Results In B and D groups the VAS score was significantly higher than that in A and C groups at 0,4,8h after the surgery(P0.05).In A and D groups Ramsay score was significantly higher than that in B or C group at 4,8,12h after the surgery(P0.05).Number of attempts and the number of successful deliveries was significantly higher in B,D groups(P0.05).The consumption of sufentanil was significantly lower in group C than that in A,B or D group(P0.05).Conclusion PCIA with flurbiprofen axetil 1.50 mg/ml combined with sufentanil 0.50 μg/ml injection could be a safe and effective method for postoperative analgesia in elderly patients.