2003•Journal of Apoplexy and Nervous DiseasesRequires access
Protein and mRNA expression of bFGF in rats brain following intracerebral hemorrhage
Hong Zhu
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Abstract
Objective To investigate the rule of protein and mRNA expression of bFGF in rats brain following intracerebral hemorrhage and supply theoretic evidence on rehabilitation of neural function. Methods To induce intracerebral hemorrhage by infusion of collagenase Ⅶ into the caudate putamen and to use behavior scores,immunohistochemistry,Northern blot and optical density scanning.Results Behavior scores in rats following intracerebral homorrhage were significantly decreased in the 7th day.Immunohistochemistry showed that bFGF was expressed extensively in rat brain, mainly in hippocampus and little in cortex.Protein and mRNA expression of bFGF was peaked in the 3rd day,and decreased little by little in the 7th day by optical density scanning.Conclusions Along with protein and mRNA expression of bFGF in rats brain following intracerebral hemorrhage being increased,the behavior deficit is significantly improved. Probably this is one of the main mechanisms for rehabilitation of neural function.