Expressionsin of bFGF mRNA and TNF protein in rats brain following brain trauma

Objective To investigate bFGF mRNA expression and of TNF protein expression after brain trauma in rats brain and providing the evidence of rehabilitation of neural function. Methods To set up brain trauma model by weight-dropping. Expression of bFGF and TNF were analyzed by Northernblot, Westernblot and optical density scanning. Results bFGF mRNA expression and TNF protein expression were peaked in the 3th day, and decreased on the 7th day detected. Conclusion TNF protein expression increased with corresponding enhancement of bFGF expression, a kind of protective factor in rats brain following brain trauma. Probably this is noe of the endogenous mechanisms for rehabilitation of neural function in the course of brain trauma.