Preparation of diflunisal sustained release tablets

Objective To prepare diflunisa1 sustained release tablets and optimize the formulation by evaluating the effect of different excipients.Methods An in vitro analytical method was established.Factors influencing the in vitro release of diflunisa1 from sustained release tablets were investigated.Results Both formulation parameters(the viscosity and amount of HPMC, the amount of lactose and different sorts of binders) and manufacture techniques(wet granulation versus direct compression, compression pressure and particle size of the raw material) affected the in-vitro release of diflunisa1 from sustained release tablets.Conclusions Sustained release diflunisa1 tablet could be prepared with appropriate release profile.