Intervention effect of simvastatin on vasculopathy in diabetic rats and its mechanism

Objective:To observe the effects of simvastatin on intercellular adhesion molecule-1(ICAM-1) levels in diabetic macroangiopathy rats and to find its possible protective effects on macroangiopathy.Methods:Duplicating rat model of diabetes complicating macroangiopathy,rats were randomly assigned to normal controlgroup(group A),normal intervention group(group B),diabetic control group(group C) and diabetic intervention group(group D).Simvastatin was given to the group B and D by gavage,while the group A and B were gavaged with corresponding normal saline.At the end of 8 weeks,the biochemical indexes,perirenal fat and serum ICAM-1 were detected and the thoracic aorta was taken for observing the pathological change.Results:The blood glucose levels in group C and D was similar,which was significantly higher than that in the group A and B(P0.01);total cholesterol,triglyceride and low density lipoprotein in group A were much higher than those in the group B,the group D was lower than the group C;ICAM-1 in the group C was much higher than that in the group A,B and D(P0.01),the group D was much lower than the group C(P0.01);the pathological changes of aorta thoracalis by light microscope showed that the group D was milder than the group C.Conclusion:Simvastatin intervention treatment can decrease TC,TG,LDL-C and ICAM-1 level and obviously alleviate or delay the occurrence and development of macroangiopathy.