2007•Chinese Journal of Laboratory DiagnosisRequires access
The effect of rosiglitazone on the blood serum Monocyte chemoattractant protein-1 levels of diabetic rats
Yan Chen
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Abstract
Objective To observe the effect of rosiglitazone on the blood serum monocyte chemoattractant protein-1(MCP-1) levels,and find its protective effects on macroangiopathy.Methods 24 Wistar rats were randomly assigned to normal control(group A) group,diabetic(group B)group and rosiglitazone treatment(group C) group.Rats in group C were treated with rosiglitazone(5 mg·kg-1·d-1)one week after the establishment of diabetic model,group A and B were treated with corresponding sodium chloride.Blood glucose levels were testsd weekly,blood MCP-1 levels were tested at the 8th week.Results At the 2nd,4th and 8th week,blood glucose levels in group B were similar to those of group C,which were much higher than those of group A.Blood MCP-1 levels in group B and group C were higher than that of group A,and blood MCP-1 levels in group C were lower than that of group B.Conclusion Rosiglitazone has the effect of antiinflammation,which may play some protection against the progress of atherogenesis in diabetic rats.