Study on Intervention of Epistan for expression of GLUT4 in Diabetic Rat Myocardiac Cell

Objective To observe the effect of hypertrophy and GLUT4 expression of myocardiac cell of diabetic rat.Methods The rats were divided into 5 groups,group A(health control),group B(diabetics),group C(epistan),group D(insulin) and group E(epistan and insulin).The diabetic model was established and then group C and E were lavaged with epistan.Group D and E were injected with insulin.The H/B ratio,glucose change and some other were observed after 11week.The GLUT4 expression was observed.Results ①H/B ratio was higher in group B,C,D and E than that in group A,H/B in group E was less than those in group B,D and C,H/B in group C was less than those in group B and D.②Blood glucose was lower in group B,C,D and E than that in group A,in group E was less than those in group B,D and C,blood glucose in group C was less than those in group B and D.③GLUT4 expression of GLUT4 in was lower in group B,C,D and E than that in group A,in group E was higher than those in group B,D and C,in group C was higher than those in group B and D.Conclusion Epistan might improve the in early stage of diabetic rat so that to inhibit hypertrophy and reconstruction of myocardiac cell and decrease blood glucose except independent insulin function.