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Correlation between LRRK2 gene S1647T polymorphism sites and Parkinson's disease in Uygur nationality of Hetian Xinjiang

Hui Yan

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Abstract

Objective To determine the correlation between LRRK2 gene S1647T polymorphism sites and Parkinson's disease(PD) in Uygur nationality.Methods A case-control study was performed between 124 PD patients and 130 normal persons.The genotypic and allelic frequencies of the LRRK2 gene S1647T polymorphism were analyzed by DNA sequencing.Results There was no difference in allele and genotype frequency between the case and the control groups(P0.05).There was no difference in allele and genotype frequency between gender or age subgroup(P0.05).Conclusions LRRK2 S1647T gene polymorphism may have nothing to do with the occurrence of Uygur population of Hetian Xinjiang.

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What this paper is about

Objective To determine the correlation between LRRK2 gene S1647T polymorphism sites and Parkinson's disease(PD) in Uygur nationality.Methods A case-control study was performed between 124 PD patients and 130 normal persons.The genotypic and allelic frequencies of the LRRK2 gene S1647T polymorphism were analyzed by DNA sequencing.Results There was no difference in allele and genotype frequency between the case and the control groups(P0.05).There was no difference in allele and genotype frequency between gender or age subgroup(P0.05).Conclusions LRRK2 S1647T gene polymorphism may have nothing to do with the occurrence of Uygur population of Hetian Xinjiang.

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Available abstract

Objective To determine the correlation between LRRK2 gene S1647T polymorphism sites and Parkinson's disease(PD) in Uygur nationality.Methods A case-control study was performed between 124 PD patients and 130 normal persons.The genotypic and allelic frequencies of the LRRK2 gene S1647T polymorphism were analyzed by DNA sequencing.Results There was no difference in allele and genotype frequency between the case and the control groups(P0.05).There was no difference in allele and genotype frequency between gender or age subgroup(P0.05).Conclusions LRRK2 S1647T gene polymorphism may have nothing to do with the occurrence of Uygur population of Hetian Xinjiang.

Key concepts: Genotype, LRRK2, Allele, Genetics, Genotype frequency, Allele frequency, Polymorphism (computer science), Gene polymorphism

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Correlation between LRRK2 gene S1647T polymorphism sites and Parkinson's disease in Uygur nationality of Hetian Xinjiang — Research Paper | ScholarLens