Correlation between LRRK2 gene S1647T polymorphism and Parkinson′s disease in Xinjiang Uygur and Han Nationalities

Objective Inherent factors play the important role in the outbreak of Parkinson's disease.The differences of genotype and mutant site can be found between different regions and races.The aim of this study is to discuss the correlation between LRRK2 gene S1647T polymorphism and Parkinson's disease(PD) and discuss the differences of allele genotypes in Uygur and Han Nationalities.Methods A case-control study was performed,which included 354 PD patients(171 cases of Uygur and 181 cases of Han) and 340 controls(160 controls of Uygur and 180 controls of Han).The LRRK2 gene S1647T polymorphism was analyzed by the methods of polymerase chain-reaction(PCR-RFLP).Then the results were verified by using the DNA sequencing method.Results The frequencies of TA+AA genotypes and A allele in Han PD group were higher comparing with those in Han control group(χ2=6.441,P=0.04 and χ2=5.389,P=0.02).Individuals who carried A allele had higher risk than the non-carriers(OR=1.436,95%CI: 1.058-1.950);However,there were no differences in allele and genotype frequencies between the Uygur PD and control(P0.05);Furthermore,we also found that the TA+AA genotype and A allele frequencies in Han PD group were both higher comparing with those in Uygur PD group(χ2=6.127,P=0.047 and χ2=4.299,P=0.038);The Han individual who carried A allele had higher risk than the Uygur individual(OR=1.387,95%CI: 1.018-1.89).There were no differences in allele and genotype frequencies between the PD and the control,nor among the age groups or between the gender groups(P0.05).The results of the multifactor Logistic regression analysis of alleles and genotypes showed that nothing but the nationality had an influence on A allele and AA or TA genotype(P0.05).Conclusion The LRRK2 S1647T gene polymorphism between the Uygur and the Han are obviously different;A allele may increase the PD risk of Xinjiang Han people and has nothing to do with the PD occurrence in Uygur population.