Association between PARK16 gene polymorphism and Parkinson disease in Uygur nationality of China

Objective To investigate the association between PARK16 gene polymorphism and Parkinson disease (PD) in Uygur nationality of Xinjiang autonomous region of China.Methods The genotypic and allelic frequences of PARK16 gene rs947211 polymorphism were analyzed by using polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) and DNA sequencing in order to research the correlation between PARK16 gene rs947211 single nucleotide polymorphism and PD in 276 PD patients of Uygur nationality and 303 healthy subjects.The factors associated with PD were determined by using multifactor logistic regression.Results The type frequencies for G allele were 55.1％ in PD subjects and 46.0％ in control subjects.The carriers of G allele had the significantly higher risk of PD (P ＜ 0.01).The multifactor logistic regression analysis revealed that GG genotype and history of exposure to pesticides were independent risk factors for PD in Xinjiang Uygur (OR =1.787,P ＜ 0.01 ; OR =1.593,P ＜ 0.05),and smoking and tea drinking were protective factors (OR =0.656,P ＜ 0.05 ; OR =0.619,P ＜ 0.01).Conclusion rs947211 polymorphism of PARK16 gene is associated with PD in this population.The G allele might be an independent risk factor and genetic marker for PD. Key words: Parkinson's disease;  PARK16 ;  Polymorphism ;  Uygur