Expression and relation of ER,IGF-IR in the different size uterine leiomyoma

Objective To investigate the relationship between uterine leiomyoma and estrogen re- ceptor or insulin-like growth factor typeI or insulin-like growth factor typeⅠreceptor.Methods The ex- pressions of estrogen receptor,insulin-like growth factor typeⅠand insulin-like growth factor typeⅠreceptor were detected by immunohistoehemistry SABC.Results Expressions of ER and IGF-1R in uterine leiomy- oma were significantly higher than those in myomertrium(P0.05).There were statistical significantly differ- ent between the group of diameter to be more than 5 cm and lower than 5 cm in the expressions of ER and IGF-1R of uterine leiomyoma.Conclusion ER and IGF-1R come into effect in the early and mid period of the uterine neoplasms' development.While the uterine neoplasms grow for a certain degree,the ability of the ER and IGF-1R that make the neoplasms grow,regulate and multiply gradualy disappears.The funtion of mechanism of ER and IGF-1R in weakened.However the reason to promote the Uterine neoplasms grow any longer possibly relates to other gateways.