Analysis Expression of ER、PR 、IGF-1、IGF-1R in the Uterine Leiomyoma and Content of NO in Venous Blood

Objective:To investigate the relationship with the growth of uterine leiomyoma and Estrogen receptor(ER)or Progesterone receptor(PR) or Iinsulin-like growth facter typeI(IGF-1)or insulin-like growth facter typeI receptor(IGF-1R) or content of NO in venous blood.Methods: 40 cases including hysterectomies on hysteromyoma were collected.expressions of ER、PR 、IGF-1、IGF-1R were used for immunohistochemistry SABC in paraffin-embeded leiomyoma and muscularis tissue slides.Griess colorimetry method was adopted to determine the content of NO in venous blood.Result: Expressions of ER and IGF-1R in uterine leiomyoma were significantly higher than those in myomertrium(P0.01),Content of NO in venous blood is indistinctive between the uterine leiomyoma group and the control group.Conclusion:there is the development reason of uterine leiomyoma that estrogen receptor in uterine leiomyoma combine with estrogen,to promote expressions of IGF-1 and IGF-1RmRNA in uterine leiomyoma significantly higher,IGF-1 combine with IGF-1R to accelerate uterine leiomyoma.