Study on the Changes of Serum Levels of Interleukin-1β(IL-1β) and C-Reactive Protein(CRP) in Patients with Acute Cerebral Infarction.

Objective To explore the role of IL-1β and CRP in the pathogenesis of acute cerebral infarction.Methods Study included 33 patients with acute cerebral infarction and 30 healthy people as control.Serum IL-1β was measured by enzyme-linked immunosorbent assay(ELISA),and serum CRP was detected by the immune rate nephelometry.Results Compared with control group,the serum levels of IL-1β and CRP within 3 days,on the 7th day and 14th day in patients with acute cerebral infarction were increased significantly(P0.05),with the levels within 3 days were the highest in patients with acute cerebral infarction.There was a positive correlation between the increasing degree of serum levels of IL-1β and CRP and the size of infarct area(P0.05).Conclusions Serum IL-1β and CRP are increased significantly in patients with acute cerebral infarction,they possibly play a key role in the pathogenesis of acute cerebral infarction,therefore anti-inflammatory drugs maybe will become potential new therapeutic agents for acute cerebral infarction.