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2009•Journal of Brain and Nervous DiseasesRequires access

Study on the changes of serum levels of interleukin-18(IL-18) in patients with acute cerebral infarction

Ning Zhang

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Abstract

Objective To explore the role of IL-18 in the pathogenesis of acute cerebral infarction.Methods The study included 46 patients with acute cerebral infarction and 30 healthy people as control.Serum IL-18 was measured by enzyme-linked immunosorbent assay(ELISA)respectively at 1,3,7,14 days.Results Compared with control group,the serum levels of IL-18 at 1,3,7,14 days in patients with acute cerebral infarction were increased significantly(P0.05),the level at 3rd day was the highest in patients with acute cerebral infarction.There was a positive correlation between the increasing degree of serum levels of IL-18 and the size of infarct area(P0.05).Conclusion Serum IL-18 was increased significantly in patients with acute cerebralinfarction,which possibly played a key role in the pathogenesis of acute cerebral infarction,therefore anti-inflammatory drugs maybe will become potential new therapeutic agents for acute cerebral infarction.

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What this paper is about

Objective To explore the role of IL-18 in the pathogenesis of acute cerebral infarction.Methods The study included 46 patients with acute cerebral infarction and 30 healthy people as control.Serum IL-18 was measured by enzyme-linked immunosorbent assay(ELISA)respectively at 1,3,7,14 days.Results Compared with control group,the serum levels of IL-18 at 1,3,7,14 days in patients with acute cerebral infarction were increased significantly(P0.05),the level at 3rd day was the highest in patients with acute cerebral infarction.There was a positive correlation between the increasing degree of serum levels of IL-18 and the size of infarct area(P0.05).Conclusion Serum IL-18 was increased significantly in patients with acute cerebralinfarction,which possibly played a key role in the pathogenesis of acute cerebral infarction,therefore anti-inflammatory drugs maybe will become potential new therapeutic agents for acute cerebral infarction.

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Available abstract

Objective To explore the role of IL-18 in the pathogenesis of acute cerebral infarction.Methods The study included 46 patients with acute cerebral infarction and 30 healthy people as control.Serum IL-18 was measured by enzyme-linked immunosorbent assay(ELISA)respectively at 1,3,7,14 days.Results Compared with control group,the serum levels of IL-18 at 1,3,7,14 days in patients with acute cerebral infarction were increased significantly(P0.05),the level at 3rd day was the highest in patients with acute cerebral infarction.There was a positive correlation between the increasing degree of serum levels of IL-18 and the size of infarct area(P0.05).Conclusion Serum IL-18 was increased significantly in patients with acute cerebralinfarction,which possibly played a key role in the pathogenesis of acute cerebral infarction,therefore anti-inflammatory drugs maybe will become potential new therapeutic agents for acute cerebral infarction.

Key concepts: Pathogenesis, Medicine, Cerebral infarction, Infarction, Internal medicine, Interleukin 6, Interleukin, Cardiology

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