Effect of Tongxinluo capsule combined with nicorandil on the vascular endothelial function in patients with coronary slow flow

Objective To study the effect of Tongxinluo capsule combined with nicorandil on the vascular endothelial function in patients with coronary slow flow(CSF).Methods 60 patients with CSF were divided into 3 groups by using a randomized,control and single blind method;control group(n =20),received routine treatment of CSF only;the observation group Ⅰ(n =20),received routine treatment plus nicorandil;the observation group Ⅱ(n =20),received routine treatment plus Tongxinluo capsule combined with nicorandil.After 6 months of treatment,the flow mediated dilatation(FMD) function in brachial artery was measured by high resolution ultrasound and NO,hs-CRP,ET-1 were detected before and after treatment.Results The FMD function in brachial artery and the level of NO,hs-CRP and ET-1 were improved significantly after therapy in observation group I and observation group Ⅱ with significant difference(P 0.05).The FMD function in brachial artery and the level of NO,hs-CRP and ET-1 were improved significantly after therapy in observation group I and observation group Ⅱ than the control group with significant difference(P 0.05);and compared with the observation group Ⅰ,after the treatment,indicator of observation group Ⅱ improved more significantly,the difference was statistically significant(P 0.05).Conclusion The Tongxinluo capsule combined with nicorandil can significantly improve the vascular endothelial function in patients with coronary slow flow.