Clinical efficacy of nicorandil in the treatment of microvascular angina and its effect on vascular endothelial function

Objective To investigate the efficacy of nicorandil in the treatment of microvascular angina and its effect on vascular endothelial function. Methods One hundred patients with microvascular angina were randomly divided into the study group and the control group, with 50 cases in each group. The control group underwent conventional anti-anginal therapy, on the basis of which the study group underwent additional nicorandil tablets for three-month continuous treatment. The plasma levels of endothelin(ET-1) and nitric oxide(NO), and serum levels of high-sensitivity C-reactive protein(hs-CRP) were measured before and after treatment respectively. Results The to-tal effective rate of symptoms was 94.0 % in the study group and 76.0% in the control group, with statistically significant difference between the two groups(P0.05). The total effective rate of curative effects on ECG was 90.0% in the study group and 72.0% in the control group, with statistically significant difference(P0.05). In the study group, the NO levels after treatment were significantly increased compared with those before treatment, while ET-1 and CRP levels were significantly reduced, with statistically significant difference(P0.01). Conclusion Nicorandil could inhibit the inflammatory cytokines and improve the endothelial function, so as to improve microvascular angina symptoms, with a significant curative effect.