Distribution and drug resistance of pathogens from blood culture samples during 2004-2009

OBJECTIVE To analyze the distribution and drug resistance of pathogens from bloodstream infection,and provide a basis for clinical anti-infection treatment.METHODS A retrospective analysis of pathogenic bacteria's distribution and drug resistance from clinical blood specimens between Jan 2004 and Dec 2009 was performed.RESULTS A total of 701 pathogenic microorganisms were isolated from 7153 blood specimens,Gram-positive cocci,Gram-negative bacilli and fungi accounted for 52.1%,34.5% and 13.4%,respectively.Coagulase-negative staphylococci(CNS) were the most common pathogens.The resistant rates of staphylococci to oxacillin were high,2 strains of Enterococcus resistant to vancomycin were detected.Among the Gram-negative bacilli,the isolated rate of Escherichia coli was 15.1%,Pseudomonas aeruginosa 4.6%,Klebsiella pneumonia 2.7%.60.4% of Escherichia coli and 36.8% of Klebsiella pneumonia produced ESBLs,and they were sensitive to imipenem,meropenem,piperacillin-tazobactam.Candida tropicalis,candida parapsilosis and candida albicans were the main fungi pathogens,they were sensitive to antifungal agents.37.6% fungi were isolated from the patients in ICU.CONCLUSION Blood culture has been on the rise during these years,the species form are diversified,and the rate of the drug resistance is high.More attention should be paid to the detection of pathogens and drug resistance in blood culture.