PHARMACOKINETICS STUDY OF SULFAMETHAZINE IN PERCH

This article first reports Pharmacokinetic of Sulfamethazine in Perch after oral administration by high performance liquid chromatography .The result demonstrates: dates of SMZ concentrations versus time were conformed to one compartment open model after a single oral administration at a dose of 200×10-6, and the primary parameters were shown bellow :Absorption rate constant (K a)was 0.096 h-1 . Time when maxium concentration was obtained(Tmax) was 21.479 h. Maxium concentration(Cmax)was 50.768 μg/ml, Absorption half life(T(1/2)Ka)was 7.250 h, Elimination half life(T(1/2)K)was 38.299 h, Area under serum concentration (AUC) was 4 138.400(mg·h)/L. We can determine the concentrations in four tissues (muscle, blood, liver and kinedy) after 0.5 h for administration and the maxium concentration was determined at 16 h after administration,Average recoveries were 80%-90% in muscle, blood and liver, and the limit of determination was 0.05×10-6.