Pharmacokinetic characteristics of kuianchun in chicken.

Kuianchun was given to 30 chickens through oral feeding at 50,100 and 200 mg/kg according to body weight respectively,and plasma samples were collected from the chickens.Kuianchun in the samples were extracted and determined.Plasma concentration-time courses of kuianchun after administration was found to be one compartment model with first order absorption and its pharmacokinetic parameters were as follows:t1/2ka =0.644 1 h,1.706 1 h and 1.428 7 h,t1/2ke=3.820 5 h,2.507 1 h and 3.225 1 h,tmax=1.852 1 h,2.959 1 h and 3.101 7 h,Cmax=0.467 9 μg/mL,0.506 2 μg/mL and 1.711 2 μg/mL,AUC=3.656 8 mg/(L·h),3.715 9 mg/(L·h) and 13.254 0 mg/(L·h) at doses of 50,100 and 200 mg/kg,respectively.The results showed that the absorption and elimination of kuianchun were fast and the kuianchun concentration in blood was low after administration.The kuianchun concentration in blood increased with the increase of doses of administration.