Effect of Edaravone on the levels of serum vascular endothelial growth factor and tumor necrosis factor-α in patients with acute cerebral infarction

Objective To investigate Edaravone on the levels of serum vascular endothelial growth factor(VEGF) and tumor necrosis factor(TNF)-α in patients with acute cerebral infarction(ACI).Methods Eighty-four ACI patients were randomly divided into the Edaravone group and control group.On the basic of ACI routine treatment,Edaravone group received Edaravone 60 mg/d intravenous drip for 14 d.Pre and 14 d,28 d post treatment,the neurological deficits of all the patients were evaluated by Scandinavian Stroke Scale(SSS);the levels of serum VEGF and TNF-α were detected at 3 d,7 d and 14 d after onset,respectively by enzyme-linked immunosorbent assay.ResultsCompared with pre treatment,SSS of post treatment in the two groups were significantly decreased(P0.05-0.01),meanwhile,which in Edaravone group at each time point were significantly decrased than control group(all P0.05).The levels of serum VEGF and TNF-α at each time point in the two groups were significantly higher than normal values,and which at 7 d after onset were significantly higher than 3 d and 14 d after onset(all P0.05).The levels of serum VEGF at each time points in Edaravone group were significantly lower than the control group(all P0.01).The levels of serum TNF-α at each time point between the two groups were no statistical significance.Conclusion Edaravone can obviously decrease the levels of serum VEGF in ACI patients and reduce the brain damage caused free radical after ACI.