The Role of Edaravone on Ischemia-repersfusion Injury in Acute Stage of Rat Kidney Transplantation

Objective:To observe the role of edaravone on rat kidney allograft in rat kidney transplantation models after 24 hours.Methods: thirty-six male SD rats were served as donors and recipients.Animals were randomly divided into the following three groups: the sham-operated group(A),regular transplantation group(B),and edaravone treatment group(C).Group B was suffered normal renal transplantation and Edaravone(10 mg·kg-1) was delivered intravenously after transplantation in Group C.The changes of renal function and the degree of ischemic reperfusion injury of kidney graft combined with the expressions of TNF-α or IL-1β were observed 24 hours after renal transplantation.Results: Compared with Group B,group C significantly decreased creatinine(301.75±27.53 vs.242.73±30.21,P0.05);TNF-α transcriptional level(0.36±0.02 vs.0.29±0.04,P0.05),expression level(212.72±20.92 vs.179.62±21.41,P0.05) and expression of IL-1β levels(44.82±10.21 vs.32.21±9.17 P0.05)were decreased.The degree of injury in group C was significantly lower than that in the group B(2.68±0.13 vs.2.02±0.21,P0.05).Conclusions: the inhibition of TNF-α and IL-1β by edaravone might play the role for rat kidney graft function protection.