Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats

Objective To study the effects of edaravone on the lung injury of severe acute pancreatitis (SAP) in rats. Methods Thirty-six SD rats were randomly divided into three groups:normal control group,model group and edaravone group,and SAP was induced by intraductal administration of 5% sodium taurocholate. Edaravone was given in edaravone group,while normal saline was given in normal control group and model group. After operation 6 h rats were executed,and dry/wet weight (D/W) ratio of lung was counted,and malondialdehyde (MDA) content,superoxide dismutase (SOD) activity in serum and lung were detected,respectively. In addition,the levels of tumor necrosis factor-α (TNF-α),interleukin-1,-6 (IL-1,-6) of serum were detected. Results The MDA content of serum and lung and the levels of TNF-α,IL-1,IL-6 in model group were markedly higher than those in normal control group and edaravone group,but D/W ratio of lung,SOD activity of serum and lung were significantly lower (P0.05). Conclusion Edaravone can alleviate lung injury of rats caused by SAP.