2002•Chinese journal of integrated traditional and Western medicineRequires access

Effects of Kangxian Ruangan Granule on Platelet Derived Growth Factor (PDGF) Induced Cell Cycle and Intracellular Calcium Concentration of Hepatic Stellate Cells

Qingjing Zhu

Abstract

Objective: To study the effect of Kangxinan Ruangan Granule (KXRGG) on platelet derived growth factor induced the cell cycle and intracellular calcium concentration. Methods: Flow cytometry and Calcium probe were used to analyse the proliferation and intracellular calcium concentration of HSC cultured in an absolutely serum free medium. Results s PDGF induced the proliferation of HSC and the increasing of intracellular calcium concentration were inhibited significantly in KXRGG treated group, especially in 5mg/ml KXRGG group as compared with control group. Conclusion: KXRGG inhibits the proliferation of HSC by influencing the intracellular concentration of calciam induced by PDGF.

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Key concepts: Intracellular, Platelet-derived growth factor receptor, Calcium in biology, Calcium, Granule (geology), Growth factor, Flow cytometry, Cell cycle