Efficacy of domperidone and hydrotalcid on bile reflux gastritis: a multicenter clinical trail

Objective To investigate the effects of domperidone and hydrotalcid on bile reflux gastritis. Methods Fifty-five patients using 24 h gastric bilirubin monitoring proven bile reflux gastritis were randomly divided into three groups. Domperidone 10 mg three times daily for 4 weeks was given to 20 patients in group A; hydrotalcid 1.0 g three times daily for 4 weeks to 15 patients in group B; and domperidone 10 mg combined with hydrotalcid 1.0 g three times daily for 4 weeks to 20 patients in group C. Dyspepsia symptoms including abdominal fullness, abdominal pain, nausea and vomiting were evaluated during visits before or 4 weeks after treatment. Four weeks after treatment, the 24 h gastric bilirubin monitoring was reexamined in all patients. Results After 4 weeks treatment all symptoms had been improved, and symptom scores were significantly decreased ( P 0.05). The total symptom improvement rate of domperidone to abdominal fullness, abdominal pain, nausea and vomiting were 85.0%, 66.7%, 84.6% and 87.5%, while that of hydrotalcid were 60.0%,80.0%,83.3% and 100.0%, and that of domperidone combined with hydrotalcid were 88.9%,82.4,83.3% and 100.0% respectively. However, there were no significant differences in the total symptom improvement rates among three groups ( P 0.05). After the medication, the total time percentage of 24 h bile reflux was remarkably decreased in each group ( P 0.05), however, there were no significant differences in the reduction rates among three groups ( P 0.05). Conclusions Domperidone can decrease the gastric bile reflux and hydrotalcid can combine bile acid, both are effective in the treatment of bile reflux gastritis.