Effect of hydrotalcid combined with domperidone on bile reflux gastritis

Objective To evaluate the effect of hydrotalcid combined with domperidone on bile reflux gastritis.Methods Ninety-four patients with bile reflux gastritis proven by gastroscopy and pathology were randomized into 3 groups: there were 31 patients in group Ⅰ which were treated with hydrotalcid 1.0g three times a day; 30 patients in group II which were treated with domperidone 10mg three times a day; 33 patients in group Ⅲ which were treated with hydrotalcid 1.0g three times a day combined with domperidone 10mg three times a day. The severity of the symptoms including abdominal pain, abdominal distention,nausea and vomiting were investigated before and four weeks after treatment.Gastroscopy was also reexamined. Results The severity of all the symptoms in the three groups decreased greatly after treatment(P0.05)and the total effective rates were 93.5%,80%,100% respectively, group Ⅲ was higher than group Ⅱ (P0.05). The total effective rates gastroscopically were 87%,73.3%,100% respectively, group Ⅲ was also higher than group Ⅱ (P0.05). Conclusion Hydrotalcid combined with prokinetics domperidone is an effective treatment method for bile reflux gastritis because its binding with intragastric bile.