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Determination of chlorogenic acid in Zhenqijiangtang Capsules by HPLC

Chuan-Hui Liu

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Abstract

Objective To establish a HPLC method for the determination of chlorogenic acid in Zhenqijiangtang capsules. Methods The HPLC method was adopted, the chromatographic system consisted of C18 column (4.6 mm×100 mm),the mobile phase was Acetonitrile-0.4% Phosphate (17:83). The content was detected at a waveleng of 327 nm, the flow rate was 0.6 mL/min. Results The chlorogenic acid had a good tincar rolatim in the range of 0.043 3-0.693 8 μg (r = 0.999 9), the average recovery was 98.39%,RSD = 0.58% (n = 6). Conolusion The established method is accuracy, sensitive and simple. It can be used for quality control of Zhenqijiangtang Capsules.

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What this paper is about

Objective To establish a HPLC method for the determination of chlorogenic acid in Zhenqijiangtang capsules. Methods The HPLC method was adopted, the chromatographic system consisted of C18 column (4.6 mm×100 mm),the mobile phase was Acetonitrile-0.4% Phosphate (17:83). The content was detected at a waveleng of 327 nm, the flow rate was 0.6 mL/min. Results The chlorogenic acid had a good tincar rolatim in the range of 0.043 3-0.693 8 μg (r = 0.999 9), the average recovery was 98.39%,RSD = 0.58% (n = 6). Conolusion The established method is accuracy, sensitive and simple. It can be used for quality control of Zhenqijiangtang Capsules.

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Available abstract

Objective To establish a HPLC method for the determination of chlorogenic acid in Zhenqijiangtang capsules. Methods The HPLC method was adopted, the chromatographic system consisted of C18 column (4.6 mm×100 mm),the mobile phase was Acetonitrile-0.4% Phosphate (17:83). The content was detected at a waveleng of 327 nm, the flow rate was 0.6 mL/min. Results The chlorogenic acid had a good tincar rolatim in the range of 0.043 3-0.693 8 μg (r = 0.999 9), the average recovery was 98.39%,RSD = 0.58% (n = 6). Conolusion The established method is accuracy, sensitive and simple. It can be used for quality control of Zhenqijiangtang Capsules.

Key concepts: Chlorogenic acid, Chromatography, Medicine, High-performance liquid chromatography, Content determination, Acetonitrile, Chemistry

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