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HPLC determination of chlorogenic acid in Dankang capsules

Yan Zhou

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Abstract

Objective:To establish an HPLC method for determination of chlorogenic acid in Dankang capsules.Method:The X Bridge TM C18 column(150 mm×4.6 mm,5 μm) was used,the mobile phase consisted of methanol-0.1% phosphoric acid(15∶85),the flow rate was 1.0 mL·min-1,the detection wavelength was at 323 nm.Results:A good linear correlation of chlorogenic acid was observed within the range of 2.58-46.44 μg·mL-1(r=0.9998).The average recovery was 97.87% with RSD 1.1%.Conclusion:The method is simple,accurate and repeatable,it can be used for the quality control of Dankang capsules.

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What this paper is about

Objective:To establish an HPLC method for determination of chlorogenic acid in Dankang capsules.Method:The X Bridge TM C18 column(150 mm×4.6 mm,5 μm) was used,the mobile phase consisted of methanol-0.1% phosphoric acid(15∶85),the flow rate was 1.0 mL·min-1,the detection wavelength was at 323 nm.Results:A good linear correlation of chlorogenic acid was observed within the range of 2.58-46.44 μg·mL-1(r=0.9998).The average recovery was 97.87% with RSD 1.1%.Conclusion:The method is simple,accurate and repeatable,it can be used for the quality control of Dankang capsules.

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Available abstract

Objective:To establish an HPLC method for determination of chlorogenic acid in Dankang capsules.Method:The X Bridge TM C18 column(150 mm×4.6 mm,5 μm) was used,the mobile phase consisted of methanol-0.1% phosphoric acid(15∶85),the flow rate was 1.0 mL·min-1,the detection wavelength was at 323 nm.Results:A good linear correlation of chlorogenic acid was observed within the range of 2.58-46.44 μg·mL-1(r=0.9998).The average recovery was 97.87% with RSD 1.1%.Conclusion:The method is simple,accurate and repeatable,it can be used for the quality control of Dankang capsules.

Key concepts: Chemistry, Chlorogenic acid, Chromatography, Phosphoric acid, High-performance liquid chromatography, Linear range, Linear relationship, Linear correlation

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