Expression of MiR-19a in Placentas From Women with Preeclampsia and Normal Pregnancy

Objective:To study the relationship of the pathogenesis of preeclampsia with miR-19a by measuring the expression of miR-19a in normal pregnancy and preeclampsia placenta.Methods:10 cases of severe preeclampsia(experimental group) and 10 normal placenta maternal placenta(control) were collected,fluorescent Real-Time quantitative PCR method was used to detect the expression of miR-19a in two different groups.Results:miR-19a expression in patients with severe preeclampsia placenta increased significantly comparing with those in normal placenta.Conclusion:miR-19a expression increased significantly in preeclampsia placenta,and there exist an connection between high expression of miR-19a and the pathogenesis of preeclampsia.