2008•Chinese Journal of Birth Health & HeredityRequires access

Expression of UII and GPR14 mRNA in placenta of patients with preeclampsia.

Qiao Fu-yua

Abstract

Objective:To study the mRNA expression of urotensinⅡ(UⅡ) and G-protein coupled receptor 14(GPR14) in placenta of preeclampsia patients and their relation to the pathogenesis of preeclampsia.Methods:Expression of UⅡ and GPR14 mRNA in placenta from 25 cases of preeclampsia(PET group,15 women with mild preeclampsia and 10 women with severe preeclampsia) and 20 cases of normal term pregnant women(control group) was detected by semi-quantitative RT-PCR.Results:Expression of UⅡ mRNA in placenta of mild and severe preeclampsia groups were both significantly higher than that in control group(P0.05).Expression of GPR14 mRNA in placenta of severe preeclampsia was significantly higher than that in control group(P0.05).Conclusion:Abnormal expression of UⅡ and its receptor may play a important role in placental ischemia /hypoxia and artherosclerosis.

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Key concepts: Preeclampsia, Placenta, Urotensin-II, Messenger RNA, Pathogenesis, Internal medicine, Medicine, Endocrinology