The Research of Apolipoprtein B,E and Angiotensinogen Gene Polymorophisms in Predisposition to CHD

Objective To explore the relationship of apolipoprotein B,E(ApoB,ApoE)and angiotensinogen(AGT)gene polymorphism with coronary heart disease(CHD).Methods Gene chip technology was performed to analyze ApoB XbaⅠ、ApoE 112/158 and angiotensinogen gene polymorphism.The allele frequency and gene type distribution were compared between groups.Results There was a significant difference in the distributuion of Apo B,ApoE and AGT gene type between patients and controls(P0.05).The frequency of X+X+ genetype and X+ allele of ApoB were significantly higher in patients with CHD than controls(P0.05);the frequency ofe3/4、e4/4 genetype ande4 allele of ApoE112/158 were higher in patients with CHD than controls(P0.05).AGT-TT gene type was related with CHD significantly(P=0.003)and T allele was more frequent significantly in CHD group than controlls(P0.05).Conclusion The Apo B,ApoE and AGT gene polymorphism may be the risk factors of CHD;X+ allele of ApoB Xba Ⅰ ande4 allele of ApoE gene and T allele of AGT gene might be the geneticmarkers of CHD.