Expression of soluble interleukin-2 receptor and tissu estrogen receptor in patients with thyroid papillary carcinoma

OBJECTIVE:To study the expression of Soluble interleukin-2 receptor (SIL-2R) and Estrogen receptor(ER) in patients with thyroid carcinoma. METHODS: Expresion of ER were detected by immunohistochemistry SP method in 50 cases of thyroid papillary carcinoma and 20 cases of follicular carcinoma and 10 cases marrow shape carcinoma.RESULTS: The SIL-2R level in patients with thyroid carcinoma were (118.20±43.50) pmol/L obviously higher than thyroid node group (50.28±12.28) pmol/L and normal control group(49.2±13.32 ) pmol/L; Serum SIL-2R level in 20 day after operation was drop to normal; There was no significant difference between thyroid carcinoma and pathological; The expression positive rate of ER in papilla shape were 67.3% obviously higher than that thyroid carcinoma of follicle (40.0%) and normal control (8.0%);The expression positive rate in primary thyroid carcinoma were 74.2% significantly highter than that in cases of recurrence (20.0%); The expression positive rate in cases without lymph node metastasis were 68.5%,highter than that in cases with lymph metastasis (46.6%). CONCLUSIONS: These suggest that there is clinical significance for distinguishing thyroid benign disease from malignant,evaluating curative effect and prognosis by measuring expression SIL-2R and ER.