Expression and clinical significance of estrogen receptor and progesterone receptor in papillary thyroid carcinoma

Objective To evaluate the expression and clinical significance of estrogen receptor(ER) and progesterone receptor(PR) in papillary thyroid carcinoma and thyroid adenom.Methods Immunohistochemistry(SABC) was used to detect the expression of ER,PR in 164 cases of papillary thyroid carcinoma,128 cases of thyroid adenoma,40 cases of normal thyroid tissue.The correlation between expression and clinical features including histological type,gender disparity and lymphatic metastasis were analyzed.Results Compared with the normal thyroid tissue,the positive rates of ER and PR were higher in papillary thyroid carcinoma and thyroid adenoma,with statistical significance(χ2 = 40.01,33.47,P 0.01;χ2 = 8.19,8.40,P 0.01).There was significant difference of ER,PR expressions between papillary thyroid carcinoma and thyroid adenoma(χ2 = 24.56,16.81,P 0.01).There was significant difference of ER,PR expressions between lymphatic metastasis and without lymphatic metastasis of papillary thyroid carcinoma.(χ2 = 18.39,8.84,P 0.01).Conclusion ER and PR both contribute to the development of papillary thyroid carcinoma.